Rapid Establishment of Tracheal Stenosis in Pigs Using Endotracheal Tube Cuff Overpressure and Electrocautery
نویسندگان
چکیده
To apply a new airway treatment to humans, preclinical studies in an appropriate animal model is needed. Canine, porcine and leporine tracheas have been employed as stenosis models using various methods such chemical caustic agents, laser, electrocautery. However, existing take long time develop (3-8 weeks) the mechanism of different from that humans. The aim present study was establish fast tracheal pigs combination cuff overpressure intubation (COI) Fourteen were divided into three groups: cautery (TC) group (n=3), COI COI-TC (n=8). Cuff (200/400/500 mmHg) applied 9-mm endotracheal tube. Tracheal (40/60 watts) performed rigid bronchoscopic electrocoagulator. After intervention, observed for 3 weeks bronchoscopy every 7 days. When cross-sectional area decreased by > 50%, it confirmed established. 14 days TC group. In group, no occurred. electrocautery (40 immediately after >1 h with pressure 200 mmHg or more resulted sufficient within Moreover, degree increased proportion time. combined use helped rapidly.
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ژورنال
عنوان ژورنال: Current medical science
سال: 2021
ISSN: ['2096-5230', '2523-899X']
DOI: https://doi.org/10.1007/s11596-021-2351-0